Abstract
A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.
Keywords:
Active site binding; HIV integrase inhibitor; Hydroxamic acid; Pyridoxine.
Copyright © 2016 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Catalytic Domain
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Female
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HIV Integrase / chemistry*
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HIV Integrase / metabolism
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HIV Integrase Inhibitors / chemical synthesis
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HIV Integrase Inhibitors / chemistry*
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HIV Integrase Inhibitors / pharmacokinetics
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HIV-1 / physiology*
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Half-Life
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Humans
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Hydroxamic Acids / chemical synthesis
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Hydroxamic Acids / chemistry*
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Hydroxamic Acids / pharmacokinetics
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Inhibitory Concentration 50
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Pyridoxine / chemistry
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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Virus Replication / drug effects
Substances
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HIV Integrase Inhibitors
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Hydroxamic Acids
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HIV Integrase
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Pyridoxine